How to Maintain Microneedling Results with CALECIM® Aftercare Routine

Microneedling Maintenance with CALECIM®

Microneedling makes tiny, controlled injuries to the skin to start its natural healing process, which boosts collagen and elastin production, and the results usually last between six to twelve months. The CALECIM® Professional aftercare routine is essential for enhancing and maintaining the skin improvements from microneedling, turning it from a short-term solution into a lasting benefit for skin health. Apply CALECIM® Professional Serum right after microneedling, then use Recovery Night Complex for the first few nights, and follow with Restorative Hydration Cream in the morning and evening, along with Multi-Action Cream as needed, to help protect your skin, minimize recovery time,

Why this works

Mechanism: Microneedling creates temporary micro-channels that stay functionally receptive for roughly ~44–66 hours. Professional Serum supplies a high-content signaling-protein complex with growth factors, cytokines and overall more than 3,000 proteins. It is designed for post-procedure skin and recovery support.
Benefits seen: Users report less redness, swelling, heat, and pain after in-clinic procedures when CALECIM® is used after treatment; studies show improved skin texture and hydration when growth-factor complexes are used with microneedling compared to microneedling
Who it’s for: Patients seeking a clinically aligned routine to protect results, including sensitive or reactive skin immediately after treatment.
Timeline: Start immediately on Day 0; keep barrier-focused care for Days 1–3. Then reintroduce the actives gradually after 72 hours if the skin is calm and your practitioner agrees. Continue daily maintenance between sessions.

Compare Your CALECIM® Options

When to compare vs. choose: If you want post-procedure comfort and long-term remodelling, pair the Professional Serum with Recovery Night Complex early, then transition to Restorative Hydration Cream and Multi-Action Cream for daily maintenance. Use the table to decide what to reach for and when.

Products	Pros	Cons
Professional Serum	It is designed specifically for immediate post-procedure (at-home and in-clinic needling). With a mild pH, it offers more than 3,000 signaling proteins to support remodeling and repair.	A serum step, still needs a hydrator and sunscreen per provider guidance
Recovery Night Complex (RNC)	Ideal for the first few nights when skin feels hot and tight, this overnight film hydrates and protects sensitive skin.	Film is best used at night because it can interfere with sunscreen and makeup during the day.
Restorative Hydration Cream	It offers daily hydration and barrier support and complements Professional Serum AM/PM	It is not intended as the immediate “post-procedure booster” (that’s Professional Serum)
Multi-Action Cream	After the skin is calm, nighttime remodeling support is provided for firmness and elasticity goals.	Introduce after the acute post-procedure phase

Step-by-Step Aftercare Routine That Preserves Results

Step 1: Day 0 on the procedure day you can leverage the micro-channel window

What to do: Post-treatment in clinic, apply CALECIM® Professional Serum. That night, cleanse gently and then re-apply Professional Serum. Finally, seal it with Recovery Night Complex.
Why: Microneedling transiently increases permeability. Professional Serum is designed for immediate post-procedure use to support and signal pathways that aid recovery. RNC’s film helps reduce TEWL and protect sensitized skin overnight.

Step 2: On Days 1–3 focus on protecting the barrier and comfort

What to do (AM): Gentle cleanse, followed by professional serum. Seal it with Restorative Hydration Cream, and then mineral sunscreen (zinc/titanium) when your provider allows. This is commonly 4–24 hours after the procedure.
What to do (PM): Gentle cleanse, followed by Professional Serum and then Recovery Night Complex overnight.
Why: The ~44–66-hour micro-pore closure window is when targeted, well-tolerated care most influences outcomes. Hydration and occlusive night film support comfort and visible downtime.

Step 3: Days 4–7 are focused on gradual return to activities and nightly remodeling

What to do: Continue Professional Serum twice daily plus Restorative Hydration Cream. If the skin is calm, many clinicians allow for the gradual reintroduction of vitamin C and very mild retinoids after 72 hours (follow your provider’s advice). Use Multi-Action Cream at night for ongoing remodelling, and keep RNC on any night of tightness/heat.
Why: Staged re-entry minimizes irritation risk and helps preserve microneedling gains.

Safety & Contraindications:

• Avoid retinoids, AHAs/BHAs, benzoyl peroxide, high-strength vitamin C, scrubs/devices, hot yoga/saunas, and heavy sweating for several days.
• Skip makeup for about 24 hours, and resume only when your provider allows.
• Mineral SPF can typically resume 4–24 hours post-procedure when tolerated.
• If you have a history of cold sores (HSV-1) and are treating perioral areas, ask your prescriber about antiviral prophylaxis.
• Red flags: escalating pain, spreading redness, pus, or fever then contact your clinic promptly.

Regimen Quick-Specs

When to start: Immediately post-procedure (Day 0).
Frequency: Professional Serum AM/PM, RNC nightly for Days 0–3 (or as needed). Hydration Cream AM/PM. Multi-Action Cream PM once skin is calm.
What it does: support recovery signaling and reduce visible downtime. Less redness, edema, warmth, and discomfort have been reported, and it aids in barrier maintenance and hydration.
Compatibility: Pair with mineral SPF; avoid strong actives for ~72 hours or per provider.
Anticipated time frame: Micro-channel receptivity ~44–66 hours; typically, a series of 3–5 sessions separated by 4–6 weeks (depending on your clinic).
Clinical professionals use it because it provides post-procedure ready serum and overnight film for comfort, followed by daily maintenance to maintain results.

How to Maintain Microneedling Results with CALECIM® Aftercare Routine

Start CALECIM® Professional Serum immediately post-microneedling, apply Recovery Night Complex at night for the first few days, and maintain with Restorative Hydration Cream (AM/PM) and Multi-Action Cream (PM). This sequence aligns with the ~44–66-hour micro-pore closure window and with clinical reports of reduced redness, edema, warmth, and discomfort when CALECIM® is used after procedures.

Protocol variations you might consider

Darker vs. lighter skin tones: The average micro-pore closure times can be longer in darker skin and shorter in lighter skin. Keep the soothing phase (Serum + RNC) accordingly and be strict with mineral SPF to mitigate PIH risk.
Energy-based combo days (e.g., fractional laser): Post-procedure application of Professional Serum has been associated with less erythema/edema/warmth/pain in split-face experiences. Use RNC that night for comfort.
At-home rollers: The same Professional Serum, and RNC night logic applies, with extra caution on hygiene and a longer hold on strong actives.

Frequently Asked Questions (FAQ)

Q1: Can I use CALECIM® Professional Serum right after microneedling?
A: Yes. It is intended for immediate post-procedure use, including after at-home microneedling, to support recovery signalling.
Q2: When can I restart retinoids and acids after microneedling?
A: Many clinicians allow gradual reintroduction after 72 hours if the skin is calm. Follow your provider’s instructions.
Q3: Do I need sunscreen the next day?
A: Yes. Mineral SPF (zinc/titanium) is typically resumed 4–24 hours post-procedure when tolerated and advised by your provider.
Q4: How long are the micro-channels open?
A: Human data suggest ~44–66 hours on average, defining a practical window for targeted, soothing topicals.

Clinical Evidence of CALECIM®’s Advanced Hair System

Study: Dr. Dan Kim, M.D.: CALECIM Serum Reduces CO2 Laser Treatment Erythema & Edema: A Randomized Controlled Double-blind Split-face Trial.
Key Metrics: The CALECIM®-treated side showed less edema starting at 3 hours post-procedure; twice as many patients in the control group had more erythema (redness).

Study: CALECIM® In-Vitro Testing.
Key Metrics: PTT-6® is validated to promote a 600% increase in skin density, an 83% increase in the skin’s production of hyaluronic acid, and a 56% increase in the skin’s production of elastin.

Study: Dr. Mitchel Goldman, Stem Cell Conditioned Media Combined With Ablative Resurfacing of the Face.
Key Metrics: At day 30, a greater decrease in wrinkling and similar improvement in elastosis were seen in the active PTT-6® group compared to the vehicle group.